Figure 2 — Melatonin downregulates angiogenesis and lymphangiogenesis by regulating tumor-associated macrophages via NLRP3 inflammasomes in lung adenocarcinoma

Research Paper|Volume 16, Issue 17|pp. 12225–12238

Melatonin downregulates angiogenesis and lymphangiogenesis by regulating tumor-associated macrophages via NLRP3 inflammasomes in lung adenocarcinoma

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Figure 2.Co-culturing THP-1 macrophages with A549 promoted TME angiogenesis and lymphangiogenesis. (A) The VEGF-A, VEGF-B, VEGF-C, CXCL8, CXCL5 protein expressions, as detected by ELISA. (B, C) Branch point quantification. Typical phase-contrast images revealing tube formation. ^*p < 0.05, ^**p < 0.01. Data provided as mean ± SD (n = 3).