Figure 6 — Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality

Research Paper|Volume 16, Issue 8|pp. 7217–7248

Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality

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Figure 6.Hepatocyte-specific METTL3 homozygous ablation by Alb-Cre mice (JAX) results in apoptosis in mouse hepatocytes. (A) Representative TUNEL staining images of paraffin-embedded liver sections from control mice and METTL3^Δhep mice (JAX) at 1 month or 3 months after birth. Scale bar = 100 μm. (B) Quantification of TUNEL-positive hepatocytes in paraffin-embedded liver sections from control mice and METTL3^Δhep mice (JAX). (C, D) qRT-PCR analysis of the expression of genes related with sphingolipid metabolism in the liver of METTL3^Δhep mice (JAX).