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Research Paper|Volume 16, Issue 2|pp. 1845–1859
Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma
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Figure 5
Figure 5.Western blotting of AKT signaling pathway-related proteins, exosome-associated proteins and PD-L1. (A) Protein bands of p-AKT, CD9, CD63 and PD-L1; (B) Relative protein expressions of p-AKT, CD9, CD63 and PD-L1. (WT + lymphoma cell + CAR-T group vs. KO + lymphoma cell + CAR-T group; WT + lymphoma cell + CAR-T + PD-L1 neutralizing antibody group vs. KO + lymphoma cell + CAR-T + PD-L1 neutralizing antibody group; **P < 0.01, nsP > 0.05; N = 3).
Figure 5 — Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma | Aging