Figure 8 — 1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

Research Paper|Volume 15, Issue 21|pp. 11740–11763

1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

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Figure 8.Overview of experimental protocols. (A) Sprague–Dawley rats were used to show effects of intraperitoneal 1,5-AF on thrombotic stroke. (B) SHRSPs were used to show effects of oral 1,5-AF on hypertension-related spontaneous stroke. (C) SAMP8 mice were used to show effects of oral 1,5-AF on aging-associated brain diseases. Abbreviations: 1,5-AF: 1,5-anhydro-D-fructose; SAMP8: senescence-accelerated mouse-prone 8; SHRSPs: stroke-prone spontaneously hypertensive rats.