Figure 5 — USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-κB signaling

Research Paper|Volume 15, Issue 21|pp. 12120–12135

USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-κB signaling

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Figure 5.miR-124-3p targeted and repressed USP14. (A) StarBase was employed to analyze the upstream miRNAs of USP14, and a Venn diagram was adopted to analyze the USP14-targeted miRNAs shared by miRmap, microT, miRanda, PicTar, and TargetScan. (B) The binding sites between miR-124-3p and USP14. (C) The targeting correlation between miR-124-3p and USP14 was verified by dual-luciferase reporter assay. (D, E) miR-124-3p mimics were transfected into EC cells, and USP14 mRNA and protein expression was assessed. NS, ^**, ^***represent P > 0.05, P < 0.01, and P < 0.001. N = 3.