Figure 5.Structural analysis of WD40-propeller variant p.G162R in CSA. Structural view of (A) WT and (B) the p.G162R variant. The CSA structure comprising the seven-bladed WD40 propeller and the helix-loop-helix motif is shown as a ribbon diagram, with p.G162R highlighted in red dots and interacting amino acids in orange sticks, as well as the amino acids relevant for TRiC-association in blue dots. The structural view of CSA (PDB entry 4A11) [13] was generated using the PyMOL molecular graphics system, version 2.4, Schrödinger, LLC.
