Figure 1 — Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

Research Paper|Volume 13, Issue 22|pp. 24655–24674

Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

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Figure 1.Association analysis identified ABO as the longevity-associated gene. (A) Manhattan plot of Genome-Wide Association Studies (GWAS) on chromosome 9; (B) Linkage Disequilibrium (LD) analysis of the four variants. a: LD map of centenarians; b: LD map of nonagenarians; c: LD map of longevity; d: LD map of young controls. (C) Interaction analysis of the four variants in the three-dimensional genome. The red triangle box shows the Topologically Associating Domains (TAD) region on the ABO gene.