Figure 5 — lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy

Research Paper|Volume 13, Issue 15|pp. 19272–19281

lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy

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Figure 5.ANRIL increases resistance of pancreatic cancer cells to gemcitabine chemotherapy. (A) MTT assay showed that overexpression of ANRIL resisted the inhibition of pancreatic cancer cells by gemcitabine, but miR-181a mimics reversed the effect which caused by ANRIL. OD value reflected the relative proliferative activity of each group. (B) Colony formation assays suggested the effects of miR-181a, ANRIL and gemcitabine on the proliferation of PANC-1 cells and BxPC-3 cells. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.