Figure 7.Diagram illustrating the proposed mechanisms mediating the beneficial effects of melatonin on meiotic phenotypes of aged oocytes. Melatonin supplement induces SIRT2 expression in oocytes from old mice, which in turn decreases the acetylation levels of H4K16, and thereupon promoting the establishment of proper kinetochore-microtubule attachment and the assembly of meiotic apparatus.
