Figure 5 — Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age

Research Paper|Volume 8, Issue 6|pp. 1223–1235

Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age

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Figure 5.CD141^hi DCs from aged subjects are impaired in their capacity to induce T regsDCs from aged subjects were stimulated with RA and sorted into CD141^hi, GARP⁺ (CD141^hi) and CD141^lo, GARP⁻ (CD141^lo) populations. The 2 sorted DC subsets were then cultured with allogenic CD4 T cells. Bar graphs depict- (A) the percentage of CD4⁺CD25⁺CD127^lo FoxP3⁺ T reg cells; (B) the level of IL-10 secretion; (C) IFN-γ secretion. Figures are mean ⁺/− S.E. of 6 different experiments.