Figure 2.Regulation of homologous enzymes by sirtuins SIRT1 and SIRT3.SIRT1 deacetylates acetyl-CoA synthetase 1 (AceCS1) and 3-hydroxy-3-methylglutaryl CoA synthase 1 (HMGCS1) in the cytoplasm. SIRT3 deacetylates acetyl-CoA synthetase 2 (AceCS2) and 3-hydroxy-3-methylglutaryl CoA synthase 2 (HMGCS2) in the mitochondrial matrix.
