Figure 10.Visualization of loss of hypertrophy during proliferation of competent cells.500
HT-p21 cells (A) were treated with IPTG (B) or IPTG plus
rapamycin (C), as indicated, or left untreated. After 3 days, plates
were washed and incubated without drugs to allow proliferation. (A)
Normal size of proliferating cells. (B) Cellular hypertrophy of
senescent cells. (C) Example 1. Clonal proliferation of competent
cells results in loss of hypertrophy. (C) Example 2. Cells that
remained arrested remained hypertrophic.
