Figure 2.Hypothetical mode of action of resveratrol and spermidine as autophagy inducers. While
resveratrol functions as an activator of the deacetylase Sirtuin 1,
spermidine inhibits one or several histone acetylases. Therefore, both
resveratrol and spermidine are expected to favor protein hypoacetylation.
However, the autophagy-relevant substrates whose deacetylation is induced
by resveratrol and spermidine are not fully characterized and it is even
not known if they are completely distinct, partially overlapping or
identical. For further details, please consult the main text.
