Review|Volume 15, Issue 23|pp 14473—14505

Traditional herbs: mechanisms to combat cellular senescence

Lei Wang^1,², Jiahui Wang², Zhihui Yang², Yue Wang², Tiejian Zhao³, Weisheng Luo⁴, Tianjian Liang², Zheng Yang²

¹Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530222, China
²Department of Medicine, Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning, Guangxi 530222, China
³Department of Physiology, College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi 530222, China
⁴Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China

* Equal contribution

Received: June 30, 2023Accepted: October 15, 2023Published: December 5, 2023

https://doi.org/10.18632/aging.205269

Copyright: © 2023 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cellular senescence plays a very important role in the ageing of organisms and age-related diseases that increase with age, a process that involves physiological, structural, biochemical and molecular changes in cells. In recent years, it has been found that the active ingredients of herbs and their natural products can prevent and control cellular senescence by affecting telomerase activity, oxidative stress response, autophagy, mitochondrial disorders, DNA damage, inflammatory response, metabolism, intestinal flora, and other factors. In this paper, we review the research information on the prevention and control of cellular senescence in Chinese herbal medicine through computer searches of PubMed, Web of Science, Science Direct and CNKI databases.