Insights from model organisms on the functions of the tumor suppressor protein LKB1: Zebrafish chips in

Yme U. van der Velden¹, Anna-Pavlina G. Haramis

¹Department of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands

Received: April 12, 2011Accepted: April 25, 2011Published: April 26, 2011

Copyright: © 2011 van der Velden et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy-metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue-specific and context-dependent effectors.